Myasthenia Gravis
Dr. Şenay AYDIN

Abstract 10.5152/gghs.2020.034

Myasthenia gravis (MG) is an autoimmune disease of the neuromuscular junction (NMJ). Autoantibodies disrupt the functions of important proteins in the NMJ, such as nicotinic acetylcholine receptor (AChR), muscle specific kinase (MuSK), and low-density lipoprotein receptor-bound protein 4 (Lrp4), causing fatigue and weakness especially in ocular, bulbar and limb muscles. In addition, the role of thymus in NMJ autoregulation and the importance of thymus pathologies in MG pathogenesis are known. In this review, we present an overview of the pathogenesis and clinical aspects of MG.

Keywords: Myasthenia gravis, mediastinal diseases, etiology.
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